細胞分裂とその過程についてわかりやすくまとめてみました！
細胞分裂は染色体が鍵を握る！
染色体とは「DNAがまとまって束になったもの」です。この束(染色体数)が何本あるかは生物によって異なっています。
ヒトの場合、一部の生まれたときから染色体に異常がある場合を除いて、全員が染色体を46本持っています。
わたしたちの46本の染色体には「ヒトの作り方」の情報が入っています。
染色体をヒトを作るための設計書として、考えていきましょう！
染色体は「ヒトの作り方」というタイトルの設計書ですが、ヒトを作るには、たくさんの情報が必要です。なので、1巻では足りません。
どれくらい必要かというと、46巻の設計書が必要です。つまり、染色体が46本必要という意味です。
ショウジョウバエの染色体の数は8本、チンパンジーはヒトよりも多い48本、魚のコイは100本です。
ショウジョウバエを作り方には8巻の「設計書」が必要で、コイの場合は100巻の「設計書」が必要ということです。
そして、この設計書の全巻セットは、すべての細胞にそれぞれ1セットずつ入っています。ヒトの場合、46巻の全巻セットが、私たちの細胞ひとつひとつに入っています。
大人の細胞の数を全部合わせると60兆個程度になると考えられていますが、この60兆個すべての細胞の核に46本の染色体が入っているので「60兆×46」本の染色体を、私たちは持っています。
これは、2,760,000,000,000,000(2760兆)本にもなります。かなりの本数ですね。
体細胞分裂は染色体の数が変わらない細胞分裂
染色体についてわかったところで、次は、体細胞分裂について学んでいきましょう！
体細胞分裂を一言で説明すると「染色体の数が変わらない細胞分裂」のことです。
ヒトの場合、まず、46本の染色体がコピーされて2倍の92本分になります。そして、これが2つにわかれて元の細胞と同じ46本の染色体の細胞が2つできます。細胞分裂前と細胞分裂後の細胞の染色体の本数は同じです。
ちなみに「体細胞」とは、生殖細胞以外の細胞のことです。体のほとんどすべての細胞と思ってください。
生殖細胞は体細胞分裂ではなく「減数分裂」という異なる細胞分裂で増殖します。この減数分裂では染色体の本数が半分になります。
減数分裂を理解するためには、体細胞分裂についてしっかりと知っておかなければなりません。
学校でまだ減数分裂について習っていない人は、今しっかり体細胞分裂を理解しておきましょう！
体細胞分裂の過程
ここからは、体細胞分裂がどのような順序で起きるか、その過程について学んでいきます。
細胞分裂は染色体の数や動きに注目します。
染色体以外の細胞小器官や成分はランダムに2つに分裂します。なので、染色体だけに注目すればOKです。
では、それぞれの段階を個別に見ていきましょう！
細胞周期
細胞は、細胞分裂が行われる「分裂期(M期)」と細胞分裂が行われていない「間期」を繰り返しています。これを細胞周期といいます。
間期 → 分裂期 → 間期 → 分裂期 → 間期 →
細胞周期は細胞の種類によって異なりますが、ほどんどの細胞で18~24時間です。M期が最も短くて、30分から2時間です。
間期
間期は「核が見える期間」です。
間期の核の中で、DNAが合成されて、DNAの量が2倍になります。染色体は長い糸状になって伸びて、ばらばらに核の中をただよっているので、光学顕微鏡(学校にあるような顕微鏡)でははっきりと見ることはできません。
間期は、G₁期・S期・G₂期と、核の中で何が行われているかによって、さらに3つに分けられています。
分裂期 (M期)
分裂期(M期)は細胞が実際に分裂する時期です。
分裂期は、体がどのような動きをするかによって、前期・中期・後期・終期の4つの段階に分けられています。
前期
前期は、有糸分裂の中で最も長い期間です。前期に、染色体が凝縮して、太く、短くなります。染色体の「糸」が編まれて「ひも」になる時期だとイメージしてください。
「ひも」になった染色体は「染色分体」とよばれます。間期にDNAが合成されて2倍になっていましたね。そのため、染色体が重複していて、中央でつながっているアルファベットのXのようなかたちをしています。
前期が終了する頃には、核小体が消失し、核膜もなくなります。そのため、細胞分裂をしている細胞では核が見えません。
また、動物細胞では、中心体が2つに分離して、正反対方向に移動していきます。教科書では「両極に移動する」と書かれているかもしれません。
生物学では「細胞」を「惑星」になぞらえて説明する
生物学では、細胞を「1つの惑星」に見立てて、記述をする場合があります。
地球では「両極」は「北極」と「南極」ですね。地図では、基本的に北極が上、南極が下にありますが、宇宙には上も下も区別がないので、正確には北極は上にあるわけではありません。
これと同じで、細胞にも上下はありません。なので「両極に移動する」と書くことで、地球における北極と南極の位置関係のような、正反対の極に移動するということを表しているのです。
そして、次の段階の中期では、「赤道面」が出てきます。
細胞分裂を勉強するときは、細胞1つを地球になぞらえて想像しながら理解していくと、わかりやすいかもしれません！
中期
中期では、染色体はさらに太く短くなり、赤道面に並びます。
再度、細胞を地球だと想像してください。赤道に沿って地球を切った面に染色体が並んでいるという状態です。
前期に核膜がなくなっているので、染色体は一面に並ぶことができます。
中期のはじめには、中心体を基点として、星状体が形成され、紡錘糸が伸びていき、紡錘体が形成されます。
後期
後期は、DNA量が2倍になっている染色分体が2つに分かれ、細胞の両極へ移動する時期です。
このとき、染色体は紡錘糸によって引っ張られます。こうして、染色分体は2つにわかれ、通常の染色体(DNA量1倍)に戻ります。
終期
終期には、両極に移動した染色体の「ひも」がほどけて「糸」の状態に戻ります。
糸がばらばらになったら困るので、染色体の周りには、再び核膜が作られ、核小体も形成され、核が見えるようになります。
一方、染色体を両極に引っ張る役目を終えた紡錘体は消失します。
終期では、細胞分裂の最終段階である「細胞質分裂」がはじまる時期でもあります。
細胞質分裂
細胞質分裂では、文字通り、細胞質の部分が分裂します。
動物の細胞では細胞の表面にできたくびれがどんどん深くなっていき、ついには2つの細胞に分かれます。植物の細胞では、ふたつの細胞の間に細胞壁が形成されます。
前述したとおり、体細胞分裂では、新しくできる2つの細胞は、それぞれきっちり46本ずつ染色体をもちますが、他の細胞小器官の数はランダムに分かれます。
つまり、ミトコンドリアが新しくできた細胞の片方には300個、もう片方には1000個入る可能性もあるということです。
体細胞分裂について理解できたら、今度は減数分裂にも挑戦してみましょう！
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